MedicalResearch.com Interview with: Jose A. Garcia Salcedo, PhD. Unidad de Enfermedades Infecciosas Hospital Universitario San Cecilio Instituto de Investigación Biosanitaria de Granada Granada Spain Medical Research: What is the background for this study? Response: Drug resistance is complicating the treatment of parasitic diseases including African trypanosomiasis, a fatal disease if left untreated. Development of a vaccine is unlikely due to parasite antigenic variation. Current chemotherapy relies primarily on four drugs. Three of these drugs access the cell’s interior through surface transporters and resistance mechanisms are largely associated with loss-of-function mutations in the involved surface drug transporters. (more…)