Anesthesiology, Pain Research / 29.10.2024

MedicalResearch.com Interview with a Vertex spokesperson.   MedicalResearch.com: What is the background for this study? What are the main findings?
  • We presented Phase 3 data for our investigational, oral pain signal inhibitor, suzetrigine, at ANESTHESIOLOGY 2024, the American Society of Anesthesiologists’ annual meeting. The Phase 3 data were previously announced in January 2024, and this is the first time the findings were presented to the medical community. The data were featured in the “Best Abstracts” session at the meeting.
  • Our Phase 3 acute pivotal program for suzetrigine included two randomized, double-blind, placebo-controlled, pivotal trials, one following abdominoplasty surgery and one following bunionectomy surgery, as well as a single arm safety and effectiveness study which enrolled patients with a broad range of surgical and non-surgical pain conditions. All three studies demonstrated compelling and consistent efficacy and safety across multiple acute pain conditions and settings.
  • Together, the data demonstrate suzetrigine’s potential to offer a safe, well tolerated and effective alternative to the current acute pain treatment paradigm, without addictive potential.
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Anesthesiology, Pain Research, Pets / 29.10.2024

As a dog owner, ensuring your furry friend's health and happiness is a primary duty and yet a challenging task. Unlike humans, dogs can't vocalize their pain, so recognizing pain is all about understanding and observing the signs. As dogs are more sensitive pets, it is easy and essential to notice the changes that occur in them. Whether a minor injury, illness or something severe, early identification is crucial to prevent your dogs from further discomfort and complications. Professional support like Mesa Emergency Vet will provide immediate pet care, and it is the dog keeper's responsibility to convey what is really happening with your dog. As you scroll down to read further, you will learn about the symptoms of your dog's pain and what you can possibly do to help them.

Behavioral Changes

Dogs are typically energetic and social creatures, but if they are not feeling well, they suddenly withdraw, become lethargic, or avoid interaction, just like how humans react to a situation. Changes in the behavior are not only unusual actions, but they may also growl, snap or even get agitated in a situation where they wouldn't normally react; if so, it has to be treated as soon as possible. If they are whining, whimpering or licking a specific area, they communicate their distress. Paying close attention to its daily behavior and treating the discomfort could soon let them relax to a normal state. (more…)