Author Interviews, McGill, Sleep Disorders / 22.08.2013
Biological Clock: Removing Protein Repressor Boosts Clock Function
MedicalResearch.com Interview with:
Ruifeng Cao, MD,PhD
Postdoctoral Fellow
Laboratory of Nahum Sonenberg
McGill University
Department of Biochemistry
Montreal, QC H3A 1A3, Canada
MedicalResearch.com: What are the main findings of the study?
Answer: Circadian (~24h) timing is a fundamental biological process, underlying cellular physiology in animals, plants, fungi, and cyanobacteria. In mammals, including humans, a circadian clock in the brain drives daily rhythms in sleep and wakefulness, feeding and metabolism, and many other essential processes. We studied how protein synthesis, which is a fundamental process underlying many biological activities, is controlled in the brain clock in mice and identified a protein that functions as a clock repressor. By removing the repressor protein, the clock function is improved.
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