AHA Journals, Author Interviews, Baylor College of Medicine Houston, Blood Pressure - Hypertension, Microbiome / 30.04.2021

MedicalResearch.com Interview with: David J. Durgan, PhD Department of Anesthesiology Baylor College of Medicine Houston, TX MedicalResearch.com: What is the background for this study? Response: Our lab and others had previously shown that gut dysbiosis is not only associated with hypertension, but actually plays a causal role. For example we have shown in both a genetic model of hypertension as well as an obstructive sleep apnea induced model of hypertension, that transplantation of their dysbiotic microbiota into normotensive recipients induced elevations in blood pressure. With this understanding our focus shifted to two new questions 1) How can we manipulate the microbiota to improve/prevent hypertension, and 2) What are the signals originating from the microbiota that have the capability to influence host blood pressure? These questions lead to the experimental design of this study. (more…)