Engineering New Vasculature Could Revolutionize Root Canal Surgery

MedicalResearch.com Interview with:
Avathamsa Athirasala, MSE and
Luiz E. Bertassoni, DDS PhD

Biomaterials and Biomechanics, School of Dentistry
Center for Regenerative Medicine, School of Medicine
Biomedical Engineering, School of Medicine
Portland OR 97201 USA

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Current clinical practices for root canal treatment involve replacing the damaged tissue with inert, synthetic materials. While these procedures are able to arrest infection and decay in the tooth, they do not restore its biological function causing it to become weaker and more prone to fractures.

We are focused on the regeneration of pulp tissue instead and in this study, we have developed a strategy to apply tissue-engineering concepts to engineer dental pulp-like tissue constructs, complete with blood vessels, which can, in principle, integrate with existing vasculature when introduced at the site of injury and form healthy pulp tissue. Continue reading