Author Interviews, Infections, mBio / 08.07.2014

Soo Chan Lee, PhD Senior Research Associate, Center for Microbial Pathogenesis, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, N.C. 27710MedicalResearch.com Interview with: Soo Chan Lee, PhD Senior Research Associate, Center for Microbial Pathogenesis, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, N.C. 27710 Medical Research: What are the main findings of the study? Dr. Soo Chan Lee: Mucor circinelloides strain isolated from recalled Chobani yogurt was found to be the most virulent subspecies M. circinelloides forma circinelloides that is commonly associated with human infections. When mice were infected with this fungus through the tail-vein, 80% mortality was observed 5 days post infection. When mice were fed with spores, the fungus survived passage through the GI tract as many as 10 days, indicating the fungus can colonize to cause infections.  Whole genome sequence analysis revealed the possibility that this fungus could produce harmful secondary metabolites that are unknown in this fungal species. (more…)