Author Interviews, Duke, Genetic Research, Leukemia, MD Anderson, UT Southwestern / 23.03.2013

MedicalResearch.com Author Interview: Jun J. Yang, Ph.D. Assistant Member Dept. of Pharm. Sci. St. Jude Children's Research Hospital 262 Danny Thomas Pl., MS313 Memphis, TN 38105 MedicalResearch.com: What are the main findings of the study? Dr. Yang: We performed a comprehensive survey of inherited genetic variations for their contribution to the susceptibility of acute lymphoblastic leukemia (ALL), the most common cancer in children. This is by far the largest study of its kind (in terms of the number of subjects involved), and also the first one to include multi-ethnic populations. We identified 4 genomic loci related to the predisposition to ALL, 2 of which contributed to racial differences in the incidence of ALL. ┬áThis study provided unequivocal evidence for inherited susceptibility of childhood ALL and pointed to novel biology of the pathogenesis of this disease. (more…)