Green Tea Ingredient Changes Metabolism of Pancreatic Cancer Cells

Wai-Nang Paul Lee, M.D. Division Chief, Division of Pediatric Endocrinology and Metabolism Professor of Pediatrics Director of Biomedical Mass Spectrometry LaboratoryMedicalResearch.com Interview with:
Wai-Nang Paul Lee, M.D.
Division Chief, Division of Pediatric Endocrinology and Metabolism
Professor of Pediatrics
Director of Biomedical Mass Spectrometry Laboratory
Harbor-UCLA

MedicalResearch: What are the main findings of the study?

Dr. Wai-Nang Lee: The study reports that EGCG, the active biologic constituent in green tea, changed the metabolism of pancreatic cancer cells by suppressing the
expression of an enzyme associated with cancer, LDHA.

The researchers also compared the effects of EGCG with those of an enzyme
inhibitor, oxamate, which is known to reduce LDHA activity, and found that
they both operated in a similar manner by disrupting the pancreatic cancer
cells metabolic system.

Scientists had believed they needed a molecular mechanism to treat cancer,
but this study shows that they can change the metabolic system and have an
impact on cancer.
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Will green tea help you lose weight?

This interview content is written by Dr Dae-Kyu Song, the corresponding and responsible author of the manuscript shown at “Park, Jae-Hyung et al. (2013).
Green tea extract with polyethylene glycol-3350 reduces body weight and improves glucose tolerance in db/db and high-fat diet mice.
Naunyn-Schmiedeberg’s Archives of Pharmacology. DOI 10.1007/s00210-013-0869-9“.

Dr Jae-Hyung Park is the first author of the manuscript and a graduate student
of Dr. Dae-Kyu Song

MedicalResearch.com: What are the main findings of the study?

Answer: At doses which could be achieved by drinking green tea on a daily basis, it has been known that green tea extract (GTE) inhibits intestinal glucose and lipid absorption when it is present in the intestinal tract. It is a reason why green tea consumption has been known to be beneficial for controlling obesity and type 2 diabetes. However, we have found that, after the intestinal absorption of GTE itself, the circulating GTE can elevate blood glucose levels by blocking cellular glucose uptake in most tissues, thereby limiting glucose utilization of the tissues. Therefore, we have tried to prolong the residence time of GTE in the intestine and block the intestinal absorption of GTE, by adding non-toxic polymer polyethylene glycol (PEG) to GTE. As a result, in 4 week treatment, the GTE+PEG regimen dramatically helps obesity-induced diabetic mice lose body weight and ameliorate glucose intolerance. Interestingly, GTE alone is without any effect.
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The Impact of Green Tea and Coffee Consumption on the Reduced Risk of Stroke

MedicalResearch.com Interview with:
Yoshihiro Kokubo, MD, PhD, FACC, FAHA, FESC

Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, 5-7-1, Fujishiro-dai, Suita, Osaka,

MedicalResearch.com: What are the main findings of the study?

Dr. Kokubo:  In this study, higher green tea (2 or more cups/day) and coffee (3 to
6 times/week, 1 or more cups/day) consumption were found to be
inversely associated with the incidences of cardiovascular disease and
stroke. Higher green tea (2 or more cups/day) or coffee (1 or more
cups/day) consumption reduced the risks of cardiovascular disease,
strokes, and its subtypes, especially in intracerebral hemorrhage (P
for interaction between green tea and coffee=0.04).
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