New Probiotic Targets Harmful Intestinal Biofilm in Crohn’s Disese Interview with:

Professor Mahmoud A. Ghannoum, PhDDirector of the Center for Medical MycologyCase Western Reserve School of Medicine and UH

Dr. Ghannoum

Professor Mahmoud A. Ghannoum, PhD
Director of the Center for Medical Mycology
Case Western Reserve School of Medicine and UH What are the main findings? 

Response: The driving force for this study was our finding that patients with Crohn’s disease had a significantly high level (or abundance) of pathogenic fungi (called Candida tropicalis) as well as bacteria (Escherichia coli, and Serratia Marcescens) compared to their non-diseased first-degree relatives. Not only were their levels high, but these organisms cooperated to form polymicrobial digestive plaque (or digestive biofilms) that aggravated the inflammatory symptoms in these patients.

Based on this we wanted to develop a probiotic that targeted these organisms and the biofilms they form. Our efforts led to the design of the novel Biohm probiotic which we tested and the results were described in our publication.

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