Author Interviews, Cancer Research, Melanoma / 22.07.2021

  MedicalResearch.com Interview with: Eleonora Leucci, Ph.D Assistant Professor Laboratory for RNA Cancer Biology Department of Oncology KU Leuven   MedicalResearch.com: What is the background for this study? Response: Back in 2016, while I was characterising the RNA SAMMSON as essential for mitochondrial translation in melanoma, I noticed that its inhibition was causing cell death across a large spectrum of melanoma cell lines and models, irrespectively of their genetic background and cell state. At that time I still did not know why the effect was so pronounced on melanoma cells, but I knew that antibiotics of the tetracycline family could also block mitochondrial translation and I thought about repurposing them to treat melanoma. (more…)
Author Interviews / 16.04.2019

MedicalResearch.com Interview with: Héctor Peinado PhD Microenvironment and Metastasis Laboratory Molecular Oncology Program Spanish National Cancer Research Center Madrid, Spain  MedicalResearch.com: What is the background for this study? What are the main findings?  Response: In this study we detected for the first time BRAF mutation by liquid biopsy in melanoma stage III patients that underwent lymphadenectomy. We obtained a novel biofluid from the drainage implanted 24-48 hours post-lymphadenectomy, called exudative seroma, and profiled BRAF mutation in circulating free DNA and extracellular vesicles. Those patients positive for BRAF mutation in the seroma had increased risk of relapse, therefore we believe that this technique identifies patients at risk of relapse by identifying residual disease. (more…)