Author Interviews, Infections, NYU / 14.12.2023
NEJM: NYU Study Finds Significant Mpox Antibody Titers After Vaccination
MedicalResearch.com Interview with:
Angélica Cifuentes Kottkamp, MD
Assistant Professor of Medicine
NYU Grossman School of Medicine
Associate Program Director
Infectious Diseases & Immunology Fellowship
Associate Director for Research & Diversity
NYU Langone Vaccine Center & VTEU
Attending Physician
H+H Bellevue Virology Clinic
Division of Infectious Diseases & Immunology
NYU Grossman School of Medicine
MedicalResearch.com: What is the background for this study? How does the JYNNEOS vaccine differ from the smallpox vaccine?
Response: JYNNEOS vaccine is a smallpox vaccine that was repurposed for Mpox given the similarities between the two viruses (smallpox and mpox). The vaccine (JYNNEOS) had been studied in people without HIV therefore there was a gap in knowledge in how this vaccine, especially the small dose (intradermal dose), would work in patients with HIV.
These patients resulted to be the most affected by the mpox outbreak suffering the worse outcomes of the disease with the highest death rates.
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