Author Interviews, Cancer Research, PNAS / 02.04.2013

MedicalResearch.com Author Interview: Prof. Eytan Domany Department of Physics of Complex Systems and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel Department of Physics of Complex Systems and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel MedicalResearch.com: What are the main findings of the study? Prof. Domany: The findings are two-fold: methodological and clinical. A novel method was introduced for personalized analysis of cancer, and was applied on large colon cancer and glioblastoma datasets. The method uses high throughput (gene expression) data to infer a pathway deregulation score (PDS) for individual tumors, for hundreds of pathways and biological processes. The method is knowledge-based in that it uses well known information about the assignment of genes to biologically relevant pathways. No detailed knowledge of the underlying networks of interactions and activations is necessary. Each tumor is represented by a few hundred of these PDSs, and further analysis uses this representation. (more…)