MedicalResearch.com Interview with:
Larry B. Goldstein, MD, FAAN, FANA, FAHA
Ruth L. Works Professor and Chairman, Department of Neurology
Co-Director, Kentucky Neuroscience Institute
KY Clinic – University of Kentucky
Lexington, KY 40536
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Extensive work in laboratory models over several decades show that d-amphetamine, combined with task-relevant experience, can facilitate recovery after stroke and traumatic brain injury affecting the cerebral cortex.
Results from clinical trials have been inconsistent, in part because preclinical data indicate that the effect of amphetamines as part of a regimen for stroke recovery is biologically complex. We conducted this multicenter pilot study to explore some of that complexity.