Author Interviews, Diabetes, Heart Disease, UCSD / 28.03.2019
Gene Transfer Improved Cardiac Function in Diabetic Mouse Model
MedicalResearch.com Interview with:
H. Kirk Hammond, MD
Professor of Medicine at University of California
San Diego
Basic research scientist and cardiologist
San Diego Veterans' Affairs Healthcare System
Dr. Hammond is winner of the 2017 William S. Middleton Award – the highest research honor in the U.S. Department of Veterans Affairs
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Worldwide, 9% of adults have diabetes, predominantly due to insulin resistance, known as Type 2 diabetes. It is associated with obesity and diets high in fat and carbohydrates. In this gene transfer study we showed that a single injection of a vector encoding a natural hormone (urocortin 2, Ucn2) increased glucose disposal and improved heart function in a model of diet-induced Type 2 diabetes in mice.
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