Author Interviews, Flu - Influenza, Genetic Research, PNAS / 10.09.2019

MedicalResearch.com Interview with: Jacob S. Yount, PhD Associate Professor Department of Microbial Infection and Immunity The Ohio State University, College of Medicine Co-Director, Viruses and Emerging Pathogens Program OSU Infectious Diseases Institute MedicalResearch.com: What is the background for this study? Response: Genetic defects in a human protein known as IFITM3 are linked to hospitalization and death upon influenza virus infections. IFITM3 is an immune system protein that can inhibit virus entry into cells and it is produced as an early response to virus infections. In order to better study the role of IFITM3 during infections, we engineered a mouse model that lacks this protein. (more…)