Addiction, Author Interviews / 17.02.2022 Interview with:

Harriet De Wit, PhD Professor of Psychiatry and Behavioral Neuroscience University of Chicago  What is the background for this study?    Response: There are numerous reports that psychedelics like LSD, taken in very small ‘microdoses’, help boost mood, cognitive function and productivity. The practice is popular in Silicon Valley and among media figures, who report remarkable beneficial effects from regular use of these microdoses. The possible antidepressant effects of LSD are plausible from a neurobiological perspective, as the drug acts directly on serotonin receptors, the same systems where SSRI’s act.  However, the effects of microdosing have not yet been validated in controlled research. In our study, we recruited healthy men and women to ingest repeated, low doses of LSD under double blind conditions.  They attended four laboratory sessions, separated by three to four days.  They were randomly assigned to one of three groups who received the same drug on all four sessions: placebo, 13 micrograms of LSD or 26 micrograms of LSD. Subjects were not told exactly what drug they were receiving until the end of the study.  We measured their mood, emotional reactivity and cognition. (more…)