University of Iowa Carver College of Medicine
Iowa City, IA, USA
MedicalResearch.com: What are the main findings of the study?
Dr. Schweizer: A clinical bundle that includes nasally screening cardiac and orthopedic surgery patients for S. aureus (both methicillin-resistant S. aureus and methicillin-susceptible S. aureus), decolonizing carriers, and changing antibiotic prophylaxis for MRSA carriers, can significantly reduce the number of gram-positive surgical site infections, S. aureus surgical site infections and MRSA surgical site infections.
MedicalResearch.com: Were any of the findings unexpected?
Dr. Schweizer: It was interesting to note that studies have shown that providing all cardiac and orthopedic surgery patients with the anti-MRSA drug vancomycin prophylactically reduced the risk of MRSA surgical site infections but there was a trend toward it being a risk factor for methicillin-susceptible S. aureus (MSSA) surgical site infections).
MedicalResearch.com: What should clinicians and patients take away from your report?
Dr. Schweizer: Many surgical site infections can be prevented using a simple bundle of interventions.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Dr. Schweizer: A large cluster randomized controlled trial comparing interventions to reduce surgical site infections should be performed.
Schweizer M ,Perencevich E ,McDanel J ,Carson J ,Formanek M ,Hafner J ,et al. Effectiveness of a bundled intervention of decolonization and prophylaxis to decrease Gram positive surgical site infections after cardiac or orthopedic surgery: systematic review and meta-analysis. BMJ 2013;346:f2743