17 Nov New Drug Might Suppress Both COVID-19 and Cancer Growth

MedicalResearch.com Interview with:

Dr. Lee

Amy S. Lee, Ph.D.
Professor of Biochemistry and Molecular Medicine
USC/Norris Cancer Center
Los Angeles, CA 90033

MedicalResearch.com: What is the background for this study?

Response: Trying to find stable host cell targets to combat SARS-CoV-2 instead of chasing after the ever-mutating virus.   

MedicalResearch.com: What should readers take away from your report?

Response: When SARS-CoV-2 infects the host cell, it creates stress leading to higher production of GRP78. Blocking GRP78 reduces the ability of the virus to multiple and infect other cells.   

MedicalResearch.com: What recommendations do you have for future research as a results of this study?

Response: More pre-clinical studies and drug development to translate these basic science discoveries into practice.

Disclosures? Amy S. Lee is a member of the scientific advisory board of BiPER Therapeutics.

Citation:

Shin, WJ., Ha, D.P., Machida, K. et al. The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein. Nat Commun 13, 6551 (2022). https://doi.org/10.1038/s41467-022-34065-3

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Last Updated on November 17, 2022 by Marie Benz MD FAAD