Integrated Approach to Laboratory Measurements to Identify Acute Kidney Diseases Interview with:

Matthew T James MD, PhDAssistant ProfessorUniversity of Calgary

Dr. James

Matthew T James MD, PhD
Assistant Professor
University of Calgary What is the background for this study? What are the main findings? 

Response: The Acute Kidney Disease and Disorders (AKD) criteria from the KDIGO Acute Kidney Injury guidelines identified many patients who do not meet existing criteria for Chronic Kidney Disease or Acute Kidney Injury (AKI), and the majority of AKD events occured in the community rather than hospital setting.

This study characterized the frequency and outcome for patients with AKD (without  AKI) as well as AKD with CKD from among over 1.1 million adults  residing in Alberta Canada who received  kidney function testing and were followed for up to 8 years.

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Peptide May Reduce Inflammation in Kidney Disease Interview with:

Rudolf Lucas, PhDProfessor Pharmacology and ToxicologyVascular Biology Center, Division of Pulmonary Medicine

Dr. Lucas

Rudolf Lucas, PhD
Professor Pharmacology and Toxicology
Vascular Biology Center, Division of Pulmonary Medicine

Michael P. Madaio, MDSydenstricker Professor and ChairmanDepartment of Medicine

Dr. Madaio

Michael P. Madaio, MD

Sydenstricker Professor and Chairman
Department of Medicine

Medical College of Georgia
Augusta University
Augusta, Georgia 30912, USA. What is the background for this study?

Response: The pro-inflammatory cytokine tumor necrosis factor (TNF) is a crucial mediator of glomerulonephritis, but the cytokine is also important in defense to bacterial infections. As such, chronically inhibiting TNF, using soluble TNF receptor constructs or neutralizing anti-TNF antibodies can promote infection.

In this study, we wanted to develop a novel therapeutic strategy to specifically inhibiting deleterious TNF signaling, while preserving the beneficial anti-bacterial actions of the cytokine.

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Is there an Association between Cannabis and Acute Kidney Injury in CKD Patients? Interview with:
"Big bags of medical #marijuana on Cannabis Culture News LIVE - watch now on" by Cannabis Culture is licensed under CC BY 2.0Praveen Kumar Potukuchi, B.Pharm, MS
The University of Tennessee Health Science Center What is the background for this study?

Response: Several case reports have indicated that synthetic cannabinoid use is associated with acute kidney injury (AKI). However, it is unclear whether similar adverse effects could occur with medicinal or recreational cannabis use. Previous research has shown that the use of medical marijuana /cannabis for an average of two weeks resulted in no serious adverse effects and no incidence of AKI.

However, there are no studies which investigated the effects of marijuana/cannabis use on the incidence of AKI in patients with advanced CKD.

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Acute Kidney Injury Risk From PCI Surgery Lower With Radial Approach

Judith Kooiman Department of Thrombosis and Hemostasis Leiden University Medical Center Leiden, The Interview with:
Judith Kooiman
Department of Thrombosis and Hemostasis
Leiden University Medical Center
Leiden, The Netherlands What are the main findings of the study?

Dr. Kooiman: The main finding of our study is that trans radial PCI (TRI) is associated with a significantly lower risk of AKI compared with trans femoral PCI (TFI), after adjustment for confounding factors.
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