MedicalResearch.com Interview with:
Shan Rajendra MBBCh, MSc , MD, FRCP, FRACP
Professor of Medicine
University of New South Wales
Director of Medicine & Clinical Executive Director
Director Gastro-Intestinal Viral Oncology Group
Ingham Institute for Applied Medical Research
MedicalResearch.com: What is the background for this study?
Response: High-risk human papillomavirus(HPV) infection has been strongly associated with a subset of Barrett’s dysplasia and oesophageal adenocarcinoma.
The research question was; Does HPV status of Barrett’s high-grade dysplasia and esophageal adenocarcinoma influence survival as in viral positive head and neck cancers?
We therefore sought to determine the prognostic significance of esophageal tumor HPV status and associated viral transcriptional markers (E6/E7 mRNA and p16INK4A) and TP53.