Author Interviews, Biomarkers, NYU, Pediatrics, Pulmonary Disease / 29.07.2018
Specific Microbial Signatures Differentiate Chronic Coughs in Children
MedicalResearch.com Interview with:
Dr. Mikhail Kazachkov MD
Director of Pediatric Pulmonology
Hassenfeld Children’s Hospital
NYU Langone Medical Center
MedicalResearch.com: What is the background for this study? How common is the problem of chronic cough in children? Is it more common in children with allergies, asthma or reflux?
Response: Chronic cough is one of the leading causes of pediatric referrals to subspecialty physicians. Its prevalence in the general pediatric population may approach 3% (Galassi et al, Epidemiol. Prev. 2005;29,Suppl.:9–13).
It is important to recognize that the main causes of chronic cough in children are completely different for those in adults. Specifically, gastroesophageal reflux and postnasal drip are not considered to be important causes of cough in children. Cough variant asthma, although is a common cause of cough in adults, does not seem to be frequently diagnosed and a cause of chronic cough in children.
The main cause of chronic wet cough in children is protracted bacterial bronchitis (Chang et al, Chest. 2017 Apr;151:884-890). It is important to recognize that neurologically impaired children have completely different pathogenesis of chronic cough, which is mostly related to aspiration into the lower airway and development of aspiration-related lung disease.
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