glucosamine Tag

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Managing long-term physical mobility is a lot like maintaining the mechanical suspension on a high-performance vehicle. Every step, jump, or squat you take relies on a thin layer of resilient cartilage and a reservoir of slippery synovial fluid to absorb impact forces across your knees and hips.

When cartilage wears down faster than your body can rebuild it, internal friction increases and joint movement loses its smooth efficiency.

If you want to support your cartilage matrix internally, choosing a targeted joint health supplement provides ingredients such as glucosamine, chondroitin, and collagen peptides that are commonly used to support joint comfort. Paired with regular activity, muscle strengthening, and a healthy weight, good nutrition is one part of keeping joints flexible over time.

[caption id="attachment_76396" align="aligncenter" width="500"]joint-stiffness-supplements-pexels Photo by Towfiqu barbhuiya: [/caption]

MedicalResearch.com Interview with: [caption id="attachment_32341" align="alignleft" width="200"]Lu Qi, MD, PhD, FAHA HCA Regents Distinguished Chair and Professor Director, Tulane University Obesity Research Center Department of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans, LA 70112 Dr. Lu Qi[/caption]

Lu Qi, MD, PhD, FAHA MD, PhD, FAHA HCA Regents Distinguished Chair and Professor Director, Tulane University Obesity Research Center Department of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans, LA 70112 

MedicalResearch.com: What is the background for this study? Response: There is evidence from previous experimental studies or cross-sectional analyses in humans linking glucosamine and a variety potentially protective effects such as improving lipids, inhibiting inflammation, and mimic a low-carb diet.  

MedicalResearch.com Interview with: [caption id="attachment_36483" align="alignleft" width="133"]Jos Runhaar, PhD Erasmus MC Department of General Practice Rotterdam The Netherlands Dr. Runhaar[/caption] Jos Runhaar, PhD Erasmus MC Department of General Practice Rotterdam The Netherlands MedicalResearch.com: What is the background for this study? What are the main findings? Response: Most international guidelines report an overall lack of efficacy of glucosamine for osteoarthrits. We however know that it is a very heterogeneous disease. Therefore, it is possible that there are certain subgroups of osteoarthritis patients that actually might have effect from glucosamine; for instance subgroups based on different pathologies underlying the clinical presentation, different co-morbidities, or different disease stages. For investigating efficacy in subgroups large sample sizes are needed, and certain methodological techniques are necessary, to get a valid and robust answer. Several years ago, a group of renowned international osteoarthritis researchers started the OA Trial Bank especially for investigating these subgroup effects of osteoarthritis treatments and collect individual patient data of worldwide-performed intervention studies in osteoarthritis patients. When using the individual patient data of multiple studies, it brings us the large sample size and allows us to use the right methods. We do these subgroup analyses in the OA Trial Bank for many different interventions, not just for glucosamine. The subgroup analyses for glucosamine and for corticosteroid injections are published, the others are ongoing (for instance exercise, orthoses and topicals) or planned and still waiting for funding. The study did show, however, that glucosamine can be extremely beneficial for pets, and specifically dogs who have joint related issues. Knowing the most valuable sources of glucosamine for dogs is important, as it can be extracted and gained from multiple sources, and each have their own varied levels of quality and potency.