Nasal Swab Can Test for Creutzfeldt–Jakob Disease

MedicalResearch.com Interview with:
Zanusso Gianluigi M.D.Ph.D.

Department of Neurosciences, Biomedicine and Movement Sciences
University of Verona
Verona, Italy

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: To determine RT-QuIC assay sensitivity and specificity in cerebrospinal fluid and olfactory mucosa in a large group of patients with a clinical diagnosis of probable, possible or suspect Creutzfeldt–Jakob disease (CJD) and controls.

In these patients, RT-QuIC testing of CSF and olfactory mucosa provided a specificity and sensitivity of 100%.

A softer swab for olfactory mucosa sampling provided the same sensitivity as using a brush .

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