MedicalResearch.com Interview with: Navindra Persaud MD, MSc, BA, BSc Department of Family and Community Medicine and Li Ka Shing Knowledge Institute St Michael’s Hospital Toronto, Ontario, Canada MedicalResearch.com: What is the background for this study? What are the main findings? Response: I used to prescribe doxylamine-pyridoxine for nausea and vomiting during pregnancy. I was taught to prescribe it. The medication was recommended as the first line medication for nausea and vomiting during pregnancy. When I looked carefully at the clinical practice guidelines that recommended this medication, they did not cite supporting studies. So I tried to find the basis for the recommendations. It was surprisingly difficult to obtain information about this commonly prescribed drug. The medication seems to be ineffective based on the results of this trial. I was also surprised that important information about the trial was hidden until now. Although some results were published in 2010, the earlier reports did not mention the fact that a difference of 3 points on the 13-point symptom scale was prespecified as the minimal important difference (or the smallest difference that a patient would deem as important). (more…)