Author Interviews, Pain Research / 28.07.2020

MedicalResearch.com Interview with: Hernan Bazan, MD DFSVS FACS CEO & Co-founder, South Rampart Pharma, LLC and Professor of Surgery, Section of Vascular/Endovascular Surgery Program Director, Vascular Surgery Fellowship Ochsner Clinic  New Orleans, LA  70121 MedicalResearch.com: What is the background for this study? What are the main findings? Response: The work in this paper is in large part due to several active and productive collaborations to address a simple problem: introduce a safer way to treat pain. That is, without the risk of opioids (abuse potential), acetaminophen/paracetamol (liver toxicity) and non-steroidal anti-inflammatory drugs (NSAIDs)/ibuprofen (kidney toxicity). Acetaminophen hepatotoxicity remains the most common cause of acute liver failure in the U.S. with inadvertent hepatotoxicity the etiology in half of all case.  Our aim was to overcome this toxicity by creating acetaminophen analogs and this paper describes the rationale for this synthesis, the library of compounds used to select the lead compounds to develop, the consistent lack of hepatotoxicity cell lines and small animals, and its ability to reduce pain and fever in small animal studies. Moreover, we explain the mechanisms of action for the lack of hepatotoxicity. One mechanism for acetaminophen-induced hepatotoxicity is via formation of the electrophilic reactive metabolite, NAPQI. Using ultraperformance liquid chromatography tandem mass spectrometry (LC-MS/MS) to detect NAPQI, we observed that after CD1 mice were exposed to high doses (600 mg/kg) of either acetaminophen or SRP compounds, only acetaminophen-, but not SRP-compound-treated mice, generated the toxic metabolite NAPQI. Another mechanism for acetaminophen hepatotoxicity is loss of hepatic tight junctions and chicken wire’ hepatic tight junctions remain intact in SRP-treated animals while these junctions are lost in acetaminophen-treated animals.  (more…)
Author Interviews, JAMA, Pain Research, Technology / 06.09.2018

MedicalResearch.com Interview with: Richard L Kravitz, MD, MSPH Professor, General Internal Medicine Director, UC Center Sacramento MedicalResearch.com: What is the background for this study? What are the main findings?  Response:  The study was designed to address tso problems. The first is that many patients with chronic pain struggling to find a workable regimen. The second is more general. Patient sometimes I hesitate to participate in clinical research because they right away do not see the relevance I directly to them selves. And have one trials are away I’m addressing both problems.  (more…)
Author Interviews, Pain Research / 10.02.2015

A/Prof Manuela Ferreira PhD Senior Research Fellow, Musculoskeletal Division Associate Professor, Sydney Medical School The George Institute for Global Health Sydney Australia MedicalResearch.com Interview with: A/Prof Manuela Ferreira PhD Senior Research Fellow, Musculoskeletal Division Associate Professor, Sydney Medical School The George Institute for Global Health Sydney Australia MedicalResearch: What is the background for this study? Dr. Ferreira: Our study was set up to look at the common triggers for sudden and moderate to severe episodes of back pain. It included 1,000 participants with this condition. Participants were interviewed in the first week their pain episode occurred in and were asked to describe their physical and psychosocial activities in the 3 days preceding pain onset. MedicalResearch: What are the main findings? Dr. Ferreira: The results of the study have shown that sudden attacks of back pain are more likely to be triggered in the morning, between 8 am and 11 am. Being distracted while engaged in manual tasks, manual tasks performed in an awkward posture, or those involving objects not close to the body and lifting heavy loads were activities that most likely would trigger a new episode of back pain, even following very brief exposure (i.e. less than 2 hours). If you feel like this is you, you should visit a round rock chiropracter to aid progress! (more…)