Author Interviews, Pain Research, Pharmacology / 09.06.2025
Hebrew University Study Sheds Light on How Paracetamol (Acetaminophen) Works
[caption id="attachment_68966" align="alignleft" width="200"] Dr. Binshtok[/caption]
MedicalResearch.com Interview with:
Prof. Alexander Binshtok PhD
Cecile and Seymour Alpert Professor in Pain Research
Hebrew University’s Faculty of Medicine and Center for Brain Sciences (ELSC)
MedicalResearch.com: What is the background for this study?
Response: Paracetamol (also known as acetaminophen) is one of the world’s most commonly used pain relievers and fever reducers, yet for decades, its precise biological mechanism has remained something of a mystery. Traditionally, scientists believed its analgesic effect stemmed from central nervous system activity—specifically through the action of its metabolite, AM404, on cannabinoid and TRPV1 receptors in the brain.
Dr. Binshtok[/caption]
MedicalResearch.com Interview with:
Prof. Alexander Binshtok PhD
Cecile and Seymour Alpert Professor in Pain Research
Hebrew University’s Faculty of Medicine and Center for Brain Sciences (ELSC)
MedicalResearch.com: What is the background for this study?
Response: Paracetamol (also known as acetaminophen) is one of the world’s most commonly used pain relievers and fever reducers, yet for decades, its precise biological mechanism has remained something of a mystery. Traditionally, scientists believed its analgesic effect stemmed from central nervous system activity—specifically through the action of its metabolite, AM404, on cannabinoid and TRPV1 receptors in the brain.