Alzheimer's - Dementia, Author Interviews, Case Western / 25.12.2025
Case Western Scientists Reverse Advanced Alzheimer’s Pathology in Mice
MedicalResearch.com Interview with:
[caption id="attachment_71888" align="alignleft" width="150"]
Dr. Pieper[/caption]
Andrew A. Pieper M.D., Ph.D.
Professor, Department of Psychiatry, School of Medicine
Professor, Department of Neurosciences
Professor, Department of Pathology
Investigator, University Hospitals Harrington Discovery Institute, Harrington Discovery Institute
Associate Director, Medical Scientist Training Program, School of Medicine
Case Western Reserve University, University Hospitals Cleveland Medical Center, and
at the Louis Stokes Cleveland VA Medical Center
MedicalResearch.com: What is the background for this study?
Response: NAD+, a central cellular energy and signaling molecule, declines with age throughout the body, including the brain. When NAD+ falls below necessary levels, cells lose their ability to carry out essential maintenance and survival functions. We found that the NAD+ decline is more severe in brains from people with Alzheimer’s disease (AD) and in mouse models of AD, whereas brains of people with AD pathology but preserved cognition show gene-expression patterns consistent with maintained NAD+ homeostasis.
Dr. Pieper[/caption]
Andrew A. Pieper M.D., Ph.D.
Professor, Department of Psychiatry, School of Medicine
Professor, Department of Neurosciences
Professor, Department of Pathology
Investigator, University Hospitals Harrington Discovery Institute, Harrington Discovery Institute
Associate Director, Medical Scientist Training Program, School of Medicine
Case Western Reserve University, University Hospitals Cleveland Medical Center, and
at the Louis Stokes Cleveland VA Medical Center
MedicalResearch.com: What is the background for this study?
Response: NAD+, a central cellular energy and signaling molecule, declines with age throughout the body, including the brain. When NAD+ falls below necessary levels, cells lose their ability to carry out essential maintenance and survival functions. We found that the NAD+ decline is more severe in brains from people with Alzheimer’s disease (AD) and in mouse models of AD, whereas brains of people with AD pathology but preserved cognition show gene-expression patterns consistent with maintained NAD+ homeostasis.