Risk of Cancer Triples Following Blood Clot in Leg

MedicalResearch.com Interview with:
Dr. Jens Sundbøll
Department of Clinical Epidemiology
Aarhus University Hospital
Aarhus, Denmark

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: The incidence of acute peripheral arterial occlusion is approximately 1.5 cases per 10,000 person-years. In comparison, the incidence rate of deep venous thrombosis is about 5-10cases per 10,000 person-years. It has been established previously that deep venous thrombosis in the lower limb and pulmonary embolism may be presenting symptoms of cancer and is associated with a poor cancer prognosis. However, whether arterial thromboembolism of the lower limb also can represent prodromal symptoms of occult cancer and worsen cancer prognosis has never been investigated.

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Venous Thrombosis: Decreased Kidney Function Raises Risk

Frits R. Rosendaal PhD Department of Clinical Epidemiology Leiden University Medical Center, Leiden, The NetherlandsMedicalResearch.com Interview with:
Frits R. Rosendaal PhD
Department of Clinical Epidemiology
Leiden University Medical Center,
Leiden, The Netherlands


MedicalResearch.com: What are the main findings of the study?

Answer: In our study, we  found that moderately to severely decreased kidney function was associated with a 2.6-fold (95%CI 2.0-3.5) increased risk of venous thrombosis as compared with normal kidney function. Several hemostatic factors showed a procoagulant shift with decreasing kidney function, most notably factor VIII and von Willebrand factor. We showed that the increased risk of venous thrombosis in chronic kidney disease could not be explained by confounding factors such as body mass index, diabetes, hospitalization, or corticosteroid use. However, we found that factor VIII and von Willebrand factor fully explained the increased risk of venous thrombosis associated with impaired kidney function.
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