Study Finds Ajoene Disrupts Biofilm in Chronic Wounds, and Enhances Antibiotic Effectiveness

MedicalResearch.com Interview with:

David Houston Senior Scientist and wound project Neem Biotech

Dr. Houston

David Houston PhD
Senior Scientist and wound project
Neem Biotech

MedicalResearch.com: What is the background for this study?  

Response: Biofilms are complex bacterial communities formed during the natural infection process as a protection mechanism and controlled by bacterial quorum sensing. These biofilm communities allow infections to spread by producing toxins that inhibit the body’s immune system, generating exopolysaccharide and changes in metabolic state that reduce the efficacy of antibiotics and activating virulence factors, which ultimately drive the spread of infection. Stopping the spread of infection by inhibition of quorum sensing has potential to manage a wide range of infections, including in wounds.

In chronically-infected wounds, the prevention of biofilm formation, disruption of mature biofilms, reduction of virulence factors and thereby the spread of infection remains clinically elusive. Quorum sensing (QS) pathways regulate microbial motility, virulence factor production and the formation and maturation of biofilms. Inhibiting QS therefore presents a potential mode of therapeutic intervention for infections.

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SkinGun™ Sprays Patient’s Own Stem Cells Onto Burns or Wounds To Accelerate Healing

MedicalResearch.com Interview with:

Thomas Bold President and CEO Communications at TrendLogic RenovaCare Inc.

Thomas Bold

Thomas Bold
President and CEO
RenovaCare Inc.

MedicalResearch.com: What is the background for the CellMist™ System? How are the stem cells harvested and processed?

Response: Our flagship CellMist™ System makes use of a patient’s own stem cells, which are sprayed onto wounds using our novel SkinGun™ device.

For patients suffering severe burns and other wounds, the prospect of a quick-healing, gentle spray containing their own stem cells will be a promising alternative to conventional skin graft surgery, which can be painful, prone to complications like infections, and slow-to-heal.

Based on preliminary case studies, CellMist™ System patients can be treated within 90 minutes of arriving in an emergency room; a patient’s stem cells are isolated, processed, and sprayed on to the wound sites for rapid healing.

The CellMist™ Solution is a liquid suspension containing a patient’s own regenerative skin stem cells. A small sample (as small as a square inch) of the patient’s skin is quickly processed to liberate the stem cells from surrounding tissue. The resulting product is referred to as the ‘CellMist™ Solution’. The CellMist™ Solution is placed in the SkinGun™ and gently sprayed onto the patient’s wound.

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