04 Jul Potassium Compound In Fruits/Vegetables May Reduce Oxidative Stress

MedicalResearch.com Interview with:

Dr. Vongpatanasin

Dr. Wanpen Vongpatanasin MD
The Norman and Audrey Kaplan Chair in Hypertension
UT Southwestern Medical Center

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Diet rich in fruits, vegetables, and dairy products, known as the DASH diet, is known to reduce blood pressure in hypertensive patients. More recently, the DASH diet was shown to reduce oxidative stress in people with and without high blood pressure . However, the main nutritional ingredient responsible for these beneficial effects of the DASH diet remain unknown. Because the DASH diet is rich in potassium (K), magnesium (Mg), and alkali, we performed a randomized, double-blinded, placebo-controlled study to compare effects of KMg Citrate (KMgCit), K Chloride (KCl), and K Citrate (KCit) to allow dissociation of the three in hypertensive and prehypertensive individuals. This study was conducted in collaboration with Drs. Charles Pak and Orson Moe at UT Southwestern, the two leading experts in the field of Mineral Metabolism. We found that oxidative stress was markedly reduced by KMgCit powder compared to placebo, K Chloride, and K Citrate. On the hand, KMgCit has no significant effects on blood pressure .

MedicalResearch.com Editor’s note:  DO NOT Take Potassium supplements unless under the direction of your health care provider.

MedicalResearch.com: What should readers take away from your report?

Response: Our study suggested that KMgCit may explain reduction in oxidative stress associated with consumption of fruits and vegetables or the DASH diet. Although clinical relevance of decreased oxidative stress associated with KMgCit is unknown at the moment, increased oxidative stress has been associated with abnormal vascular tone during exercise and exercise intolerance. Increased oxidative stress has also been linked to development of insulin resistance and diabetes mellitus. Increased levels of plasma oxidative stress 8-isoprostane has been associated with increased risk of atherosclerosis in a population-based study of healthy young adults as well as cardiovascular events in patients with atrial fibrillation and acute coronary syndrome, which was independent of traditional cardiovascular risk factors.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: More studies are needed to determine long term effects of potassium magnesium citrate supplementation on exercise capacity, insulin sensitivity, and cardiovascular outcomes in hypertensive patients.

MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.

Citation:

Effects of Potassium Magnesium Citrate Supplementation on 24-hour Ambulatory Blood Pressure and Oxidative Stress Marker in Prehypertensive and Hypertensive Subjects

Wanpen Vongpatanasin, MD, Poghni Peri-Okonny, MD, Alejandro Velasco, MD, Debbie Arbique, DNP, FNP, Zhongyun Wang, MD, Priya Ravikumar, PhD, Beverly Adams-Huet, M.S, Orson W. Moe, MD, Charles Y.C. Pak, MD

doi:10.1016/j.amjcard.2016.06.041
Available online 28 June 2016

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

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MedicalResearch.com Editor’s note:  DO NOT Take Potassium supplements unless under the direction of your health care provider.

Last Updated on July 4, 2016 by Marie Benz MD FAAD