Reclast, Zometa (zoledronate) Reduced Fractures in Osteopenic Older Women Interview with:

Prof Ian Reid Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand

Prof. Reid

Prof Ian Reid MD
Faculty of Medical and Health Sciences
University of Auckland
Auckland New Zealand What is the background for this study? 

Response: Bisphosphonates prevent fractures in patients with osteoporosis, but their efficacy in women with osteopenia is unknown. Most fractures in postmenopausal women occur in osteopenic patients, so therapies with efficacy in osteopenia are needed.  What are the main findings?

Response: Fragility fractures, both non-vertebral and vertebral, were reduced by about one-third in this cohort of osteopenic women treated with zoledronate infusions every 18 months, without the use of calcium supplements.

Serious adverse events, including cancer and cardiovascular events, appeared to be less frequent  in the zoledronate group. What should readers take away from your report?

Response: The treatment of osteopenic women aged over 65 with zoledronate every 18 months is an effective way to prevent fractures. What recommendations do you have for future research as a result of this work? 

Response: More detailed analyses of subgroups in this study are being undertaken, and suggest that efficacy is generalised across the whole cohort. 


Fracture Prevention with Zoledronate in Older Women with Osteopenia
Ian R. Reid, M.D., Anne M. Horne, M.B., Ch.B., Borislav Mihov, B.Phty.,
Angela Stewart, R.N., Elizabeth Garratt, B.Nurs., Sumwai Wong, B.Sc.,
Katy R. Wiessing, B.Sc., Mark J. Bolland, Ph.D., Sonja Bastin, M.B., Ch.B.,
and Gregory D. Gamble, M.Sc.

December 20, 2018 N Engl J Med 2018; 379:2407-2416
DOI: 10.1056/NEJMoa1808082


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