19 Feb Risk of Spontaneous Abortion & Birth Defects with Oral Yeast Drug During Pregnancy
MedicalResearch.com Interview with:
Anick Bérard PhD FISPE
Research chair FRQS on Medications and Pregnancy
Director, Réseau Québécois de recherche sur le médicament
Professor, Research Chair on Medications, Pregnancy and Lactation
Faculty of Pharmacy, University of Montrealand
Director, Research Unit on Medications and Pregnancy
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Yeast infections are common during pregnancy (10%). Although topical treatments are first-line therapies, yeast infections during gestation are often more severe and are resistant to topical options. Hence, low dose oral fluconazole is often the treatment of choice for pregnant women (1 dose for 1 day).
Human and animal studies have shown that high dose of fluconazole is teratogenic.Few studies are available for the risk associated with low dose of fluconazole (the most used during pregnancy). Also, no one has studied the combined effect of low- and high-dose fluconazole use during pregnancy on overall adverse pregnancy outcomes (spontaneous abortions, stillbirths and major malformations).
MedicalResearch.com: What should readers take away from your report?
Response: Regardless of dosage, oral fluconazole use is associated with the risk of spontaneous abortions. However, only high dose of fluconazole use during pregnancy is associated with cardiac defect – low dose is not associated with the risk of malformations. Oral fluconazole (low- or high-dose) is not associated with the risk of stillbirth. This is reassuring given that low-dose is the most frequently used.yeast infections should be treated during pregnancy.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: Our study is consistent with what is already known. However, studies with even larger sample sizes would be needed to take into account potential residual confounding.
Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case–control studies
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