Immunotherapy Gel Sprayed on Surgical Site May Reduce Cancer Recurrence

MedicalResearch.comInterview with:

Zhen Gu, Ph.D.
Professor, Department of Bioengineering
University of California, Los Angeles (UCLA)
Dr. Zhen Gu

Zhen Gu, Ph.D.
Professor, Department of Bioengineering
University of California, Los Angeles (UCLA)

MedicalResearch.com:  What is the background for this study?  What are the main findings?

Response: Despite improvements in surgical techniques, local residual tumor micro infiltration and circulating tumor cells continue causing tumor recurrence after resection. 

Calcium carbonate nanoparticles could scavenge H+ in the surgical wound, reserving the immunosuppressive tumor microenvironment and promoting the antitumor immuneresponses. 

MedicalResearch.com: What should readers take away from your report?

Response: This treatment method is quite straightforward. The sprayed gel-based delivery platform enhances the local retention of immunotherapeutics, improves their effect on tumor-infiltrating lymphocytes, and potentially reduces toxicity, compared to the systemic treatment.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: This could be a platform technology, with different drugs loaded (e.g., aPD1, aPDL1…) for achieving potential personalized medication.

No disclosures


Qian Chen, Chao Wang, Xudong Zhang, Guojun Chen, Quanyin Hu,Hongjun Li, Jinqiang Wang, Di Wen, Yuqi Zhang, Yifei Lu, Guang Yang, ChenJiang, Jun Wang, Gianpietro Dotti, Zhen Gu. In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment. Nature Nanotechnology, 2018; DOI: 10.1038/s41565-018-0319-4

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Last Updated on December 12, 2018 by Marie Benz MD FAAD