Failure of Dental Fillings Is At Least Partially Genetically Determined Interview with:
“Dental Mold_002” by Ano Lobb is licensed under CC BY 2.0
Alexandre R. Vieira, DDS. MS, PhD
Professor, Director of Clinical Research,  Director of Student Research
Department of Oral Biology
Center for Craniofacial and Dental Genetics
Department of Pediatric Dentistry
School of Dental Medicine
Department of Human Genetics
Graduate School of Public Health
Clinical and Translational Sciences Institute
University of Pittsburgh What is the background for this study? What are the main findings?

Response: One aspect is the dilemma between continuing to use dental amalgams and the perception that composite resins are not as durable.

We show that composite resin restorations can perform similarly to dental amalgams for the first 5 years. But the most remarkable is that composite resin failures may be related to certain individual risk factors, such as genetic variation. What should readers take away from your report?

Response: That the time in which the dentist will take into consideration the individual genetic make-up is near. Genetic information may provide a tool to determine follow-up and recall periodicity, and delineate better risks regarding certain treatments. What recommendations do you have for future research as a result of this study?

Response: Investigators should rethink phenotypes they are studying, and should consider defining disease and risk based on longitudinal information. Thank you for your contribution to the community.


Alexandre R. Vieira, Marília B. Silva, Kesia K. A. Souza, Arnôldo V. A. Filho, Aronita Rosenblatt, Adriana Modesto. A Pragmatic Study Shows Failure of Dental Composite Fillings Is Genetically Determined: A Contribution to the Discussion on Dental AmalgamsFrontiers in Medicine, 2017; 4 DOI: 10.3389/fmed.2017.00186

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

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Last Updated on November 7, 2017 by Marie Benz MD FAAD