17 Nov New Drug Might Suppress Both COVID-19 and Cancer Growth
MedicalResearch.com Interview with:
Amy S. Lee, Ph.D.Professor of Biochemistry and Molecular Medicine USC/Norris Cancer Center Los Angeles, CA 90033
MedicalResearch.com: What is the background for this study?
Response: Trying to find stable host cell targets to combat SARS-CoV-2 instead of chasing after the ever-mutating virus.
MedicalResearch.com: What should readers take away from your report?
Response: When SARS-CoV-2 infects the host cell, it creates stress leading to higher production of GRP78. Blocking GRP78 reduces the ability of the virus to multiple and infect other cells.
MedicalResearch.com: What recommendations do you have for future research as a results of this study?
Response: More pre-clinical studies and drug development to translate these basic science discoveries into practice.
Disclosures? Amy S. Lee is a member of the scientific advisory board of BiPER Therapeutics.
Shin, WJ., Ha, D.P., Machida, K. et al. The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein. Nat Commun 13, 6551 (2022). https://doi.org/10.1038/s41467-022-34065-3
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