Alberto J. Espay, MD, MSc, FAAN Professor of Neurology Director and Endowed Chair Gardner Family Center for Parkinson's disease and Movement Disorders University of Cincinnati Academic Health Center

24 Apr Parkinson’s Disease: Extended Release Levodopa Tested to Reduce Motor Fluctuations

Posted at 10:55h in Author Interviews, Neurological Disorders, Parkinson's by

MedicalResearch.com Interview with:

Alberto J. Espay, MD, MSc, FAANProfessor of Neurology Director and Endowed Chair Gardner Family Center for Parkinson's disease and Movement Disorders University of Cincinnati Academic Health Center

Dr. Espay

Alberto J. Espay, MD, MSc, FAAN
Professor of Neurology
Director and Endowed Chair
Gardner Family Center for Parkinson’s disease and Movement Disorders
University of Cincinnati Academic Health Center

MedicalResearch.com: What is the background for this study?

Response: This study was meant to address the gap that current oral levodopa formulations do not suffice to lessen motor fluctuations in people with Parkinson’s disease. IPX203 is a unique extended-release formulation of levodopa.

MedicalResearch.com: What are the main findings?

Response:  IPX203 dosed at three daily doses was safe and extended the “on time” compared to five daily doses of standard levodopa.

MedicalResearch.com: What should readers take away from your report?

Response: We have shown that such response is sustained for at least the 9 months of open-label extension data we are presenting. 

MedicalResearch.com: What recommendations do you have for future research as a results of this study?

Response: Future research may test the value of using IPX203 earlier in the disease, even prior to the development of motor fluctuations.

Disclosures: I was a primary investigator for the IPX203 and have received compensation as scientific advisor from Amneal, the owner of IPX203.

Citation: AAN 2023 abstract

Long-term Safety and Efficacy of IPX203 in Parkinson’s Disease Patients with Motor Fluctuations: A 9-Month Open-label Extension Trial

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Last Updated on April 24, 2023 by Marie Benz

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