Anna Rosemarie Yousaf MD CDC: U.S. Centers for Disease Control and Prevention

CDC Reports Outcomes of Pediatric Multisystem Inflammatory Syndrome After COVID Interview with:

Anna Rosemarie Yousaf MDCDC: U.S. Centers for Disease Control and Prevention

Dr. Yousaf

Anna Rosemarie Yousaf MD
CDC: U.S. Centers for Disease Control and Prevention What is the background for this study? What are the main findings?

Response: Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious complication following SARS-CoV-2 infection or COVID-19 illness in children characterized by fever and multiple organ inflammation.

This study looks at data from children with MIS-C reported to CDC’s national MIS-C surveillance system and compares the characteristics of children who died to children who survived. What should readers take away from your report?

Response: Throughout most of the COVID-19 pandemic, children who died from MIS-C were 16 to 20 years old. They also resided in the Southern U.S., had MIS-C onset early in the pandemic, had underlying medical conditions, and had severe organ involvement during their MIS-C illness. None of the children who died were vaccinated for COVID-19 despite 30% of them being eligible for vaccination prior to their MIS-C illness. What recommendations do you have for future research as a results of this study?

Response: In this investigation, we describe the differences between those children with MIS-C who died and did not. In future analyses, we will use multivariable modeling in order to control for multiple risk factors that may be associated with death in these children.

We will also continue to perform surveillance to evaluate factors associated with severe illness and death in children with MIS-C. Is there anything else you would like to add? Any disclosures?

Response: Although we could not calculate a COVID-19 vaccine effectiveness estimate with these data, we found that none of the children who died were vaccinated. Other studies have shown that COVID-19 vaccination decreases the risk of MIS-C.

No disclosures.


Ptak K, Szymońska I, Olchawa-Czech A, Kukla K, Cisowska M, Kwinta P. Comparison of the course of multisystem inflammatory syndrome in children during different pandemic waves. Eur J Pediatr. 2023 Apr;182(4):1647-1656. doi: 10.1007/s00431-022-04790-4. Epub 2023 Jan 31. PMID: 36719477; PMCID: PMC9887239.

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Last Updated on November 1, 2023 by Marie Benz