Author Interviews, Dermatology, Genetic Research, Nature, Rheumatology / 28.03.2024
Gene Mutation Discovered That May Lead Some Psoriasis Patients to Develop Arthritis
MedicalResearch.com Interview with:
Chelisa Cardinez PhD
Postdoctoral Researcher
The Burr Laboratory- Cancer Immunology and Epigenetics
Genome Sciences and Cancer Division
The John Curtin School of Medical Research
The Australian National University
Canberra, Australia
MedicalResearch.com: What is the background for this study?
Response: Psoriasis is a skin inflammatory disease that affects approximately 2-3% of the population.
Previous research had identified that the cytokine IL-17 drives the development of this disease. However, key questions that remained unknown about psoriasis included where did the IL-17 come from, and why do some patients with psoriasis also go on to develop systemic inflammatory conditions such as arthritis. Our research aimed to address these questions using a gain of function (GoF) mouse model that carried a genetic variant in a gene called IKBKB.
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