Author Interviews, Gout / 27.06.2025
EULAR 2025: Monthly KRYSTEXXA with MTX Matched Safety & Efficacy of Biweekly treatment for Uncontrolled Gout
MedicalResearch.com Interview with:
Orrin M. Troum, MD
Orrin M. Troum, MD, is a Clinical Professor of Medicine and
Voluntary Faculty Member of the Division of Rheumatology
Keck School of Medicine- UCLA
Director, Clinical Rheumatology Research
Providence St John's Hospital
Santa Monica, California
MedicalResearch.com: What is the background for this study? Who is more likely to develop uncontrolled gout?
Response: The Phase 4, open-label FORWARD trial was designed to evaluate the safety and efficacy of less frequent, monthly dosing of KRYSTEXXA® (pegloticase) co-administered with methotrexate (MTX) in patients with uncontrolled gout. KRYSTEXXA remains the only FDA-approved therapy for this challenging condition, but with continued research like the FORWARD trial, we can further improve and evolve the treatment landscape for patients. This study reflects a broader effort to optimize gout care with approaches that are not only effective but also more sustainable in real-world settings.
Uncontrolled gout happens when gout is not properly treated and uric acid levels continue to rise, which can have a damaging impact on the body beyond the pain of regular flares. Those experiencing uncontrolled gout continue to have signs and symptoms of gout despite taking oral urate-lowering medicines.
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