Link Between Skin Disease Hidradenitis Suppurativa and Inflammatory Bowel Disease

MedicalResearch.com Interview with:

Hidradenitis suppurativa- DermNetNZ

Hidradenitis suppurativa- DermNetNZ

Prof Ching-Chi Chi, MD, MMS, DPhil (Oxford)
Department of Dermatology
Chang Gung Memorial Hospital, Linkou
Guishan Dist, Taoyuan 33305
Taiwan

MedicalResearch.com: What is the background for this study?

Response: Hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD) are inflammatory diseases that share common clinical manifestations, genetic susceptibility, and immunologic features. For example, both diseases have similar clinical manifestations in the skin and gut, characterized by sterile abscesses in perineal and inguinal areas, scarring, and sinus tract formation. Both diseases have been associated with an increased prevalence of spondyloarthropathy, have common risk factors (smoking and obesity), and respond well to tumor necrosis factor-inhibitors. Some studies have suggested a link between HS and IBD, but data on the association of HS and IBD remain inconsistent and unclear. Therefore, we conducted a meta-analysis to investigate the association of hidradenitis suppurativ with IBD.

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Drugs That Target Th17 Cells Can Improve Debilitating Skin Disease Hidradenitis suppurativa

MedicalResearch.com Interview with:

Dr Jean Fletcher Assistant Professor Schools of Medicine and Biochemistry & Immunology Trinity College Dublin, the University of Dublin Dublin, Ireland

Hidradenitis suppurativa
Wikipedia image

Dr Jean Fletcher
Assistant Professor
Schools of Medicine and Biochemistry & Immunology
Trinity College Dublin, the University of Dublin
Dublin, Ireland

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Hidradenitis suppurativa (HS) is an inflammatory skin disease which causes deep, painful lesions in areas such as the underarms and groin. 1-4% of people are thought to suffer from the disease, however as it is under recognised and often misdiagnosed these may be conservative estimates. The pain and distress associated with HS leads to a poor quality of life with many patients experiencing depression.
Current interventions include combinations of antibiotics, surgery to remove lesions and more recently the use of the biologic therapies such as TNF inhibitors; however these are often ineffective and there is a pressing need for more effective treatments.

The cause of Hidradenitis suppurativa is unknown, however there are known risk factors which include smoking and obesity, and there is an association with inflammatory bowel disease, which suggests that dysregulation of the immune system may play a role.

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Hidradenitis Suppurativa Linked To Increased Risk of Metabolic Syndrome

MedicalResearch.com Interview :
Iben Marie Miller, MD
Department of Dermatology
Roskilde Hospital, Roskilde
Department of Health and Medical Sciences,
University of Copenhagen, Copenhagen, Denmark

Medical Research: What are the main findings of the study?

Dr. Miller: Using a cross-sectional design based on data from a Hidradenitis Suppurativa (HS) group recruited from the hospital (32 individuals), an HS group recruited from the general population (326 individuals) and 14,851 individuals without Hidradenitis Suppurativa, we investigated a possible association of Hidradenitis Suppurativa and the metabolic syndrome. We found that the HS groups had 2 to 4 times odds of having the metabolic syndrome when compared to individuals without HS leaving Hidradenitis Suppurativa patients at a high cardiovascular risk. Furthermore, we found that the odds were higher for the HS group from the hospital in comparison to the Hidradenitis Suppurativa group from the general population.

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