Allergies, Author Interviews, Pediatrics / 24.07.2020

MedicalResearch.com Interview with: Kirsten P Perrett MD PhD Group Leader/Clinician Scientist Fellow Population Allergy Research Group and Melbourne Children's Trial Centre Murdoch Children's Research Institute   Rachel L Peters PhD Murdoch Children’s Research Institute Department of Paediatrics The University of Melbourne Parkville, Australia MedicalResearch.com: What is the background for this study? cashews-wikipedia-image Response: The prevalence of food allergy has increased over the last 1-2 decades. Historically, parents were advised to withhold the introduction of allergenic foods, such as peanut or egg, until after the infant was 1-3 years of age in the hope that it would prevent food allergy. However, recent evidence has shown that introducing peanut and egg in the first year of life, reduces the risk of allergy to that food. This has led to a paradigm shift in infant feeding advice from active avoidance to timely introduction. However, there has not been any research advising on the timing of tree nuts, a common cause of food allergy, MedicalResearch.com: What are the main findings? Response: Our study of nearly 3000 children in the population-based HealthNuts study in Australia, found that only 5% had eaten cashew by age 12 months. Interestingly, no child who consumed cashew by age 12 months, developed cashew allergy at age 6 years; conversely 3.6% of those who had not consumed cashew by age 12 months did develop cashew allergy at age 6 years. Our findings suggest that introducing cashew in the first year of life may reduce the risk of cashew allergy. (more…)
Allergies, Author Interviews, Dermatology / 22.07.2020

MedicalResearch.com Interview with: Emma Guttman-Yassky, MD, PhD Professor of Dermatology and Immunology Vice Chair of the Department of Dermatology Icahn School of Medicine MedicalResearch.com: What is the background for this study? What is the importance of differentiating these two skin conditions?   Response: The background is that up to now skin biopsies were considered the gold standard for obtaining skin biomarkers of atopic dermatitis/AD and psoriasis that are linked to disease activity in skin and for obtaining the cutaneous gene and protein expression fingerprint of each individual disease. Biopsies are also used in clinical trials to obtain the skin phenotype. However biopsies are invasive, painful and scarring. Thus we need less invasive means to profile diseases and obtain biomarkers. Tape strips is a minimally invasive approach to sample and study the skin. However, prior studies using tape strips could not fully capture the phenotype of the diseases and also sampling the recovery rate was less than optimal, not allowing this approach to be widely used. Psoriasis and AD are the most common inflammatory skin diseases, but these diseases are treated very differently and in some cases are very difficult to differentiate between them clinically and even in biopsies.  (more…)