Aging, Author Interviews, Exercise - Fitness / 15.01.2026
Duke-NUS Medical School Identifies Signal Explaining Why Aging Muscles Lose Ability to Maintain Mass and Function
[caption id="attachment_72010" align="alignleft" width="500"] Cancer and Stem Cell Biology Duke-NUS Medical School Lab Team Members[/caption]
MedicalResearch.com Interview with:
Hung-Wen Tang, PhD
Assistant Professor
Cancer and Stem Cell Biology
Duke-NUS Medical School
Singapore
MedicalResearch.com: What is the background for this study?
Response: As we age, we naturally lose muscle strength and function — a condition known as sarcopenia. This makes everyday activities harder and increases the risk of falls, frailty, and loss of independence. Scientists have long known that a growth pathway in muscle cells called mTORC1 becomes overactive with age and contributes to muscle decline. However, the underlying cause of this overactivation remained unclear.
Cancer and Stem Cell Biology Duke-NUS Medical School Lab Team Members[/caption]
MedicalResearch.com Interview with:
Hung-Wen Tang, PhD
Assistant Professor
Cancer and Stem Cell Biology
Duke-NUS Medical School
Singapore
MedicalResearch.com: What is the background for this study?
Response: As we age, we naturally lose muscle strength and function — a condition known as sarcopenia. This makes everyday activities harder and increases the risk of falls, frailty, and loss of independence. Scientists have long known that a growth pathway in muscle cells called mTORC1 becomes overactive with age and contributes to muscle decline. However, the underlying cause of this overactivation remained unclear.