Author Interviews, Melanoma, NYU/NYMC / 20.02.2026
Melanoma: NYU Study Outlines Mechanisms Tumors Use to Sustain Blood Supply and Escape Immune Detection
[caption id="attachment_72519" align="alignleft" width="200"] Dr. Berico[/caption]
MedicalResearch.com Interview with:
Pietro Berico, M.Sc., Ph.D.
Postdoctoral research fellow
Hernando Lab
NYU Grossman School of Medicine
NYU Langone Health
New York, NY 1001
MedicalResearch.com: What is the background for this study?
Response: “Cutaneous melanoma arises under chronic UV irradiation, which selects for aggressive malignant clones. Paradoxically, its high mutational burden also promotes neoantigen formation and robust immune activation. Consequently, melanoma must establish immune evasion mechanisms from the earliest stages of tumor development. The lack of specific genetic mutational patterns linked to immune escape points toward non-mutational mechanisms, such as epigenetic reprogramming.
Dr. Berico[/caption]
MedicalResearch.com Interview with:
Pietro Berico, M.Sc., Ph.D.
Postdoctoral research fellow
Hernando Lab
NYU Grossman School of Medicine
NYU Langone Health
New York, NY 1001
MedicalResearch.com: What is the background for this study?
Response: “Cutaneous melanoma arises under chronic UV irradiation, which selects for aggressive malignant clones. Paradoxically, its high mutational burden also promotes neoantigen formation and robust immune activation. Consequently, melanoma must establish immune evasion mechanisms from the earliest stages of tumor development. The lack of specific genetic mutational patterns linked to immune escape points toward non-mutational mechanisms, such as epigenetic reprogramming.