MedicalResearch.com Interview with: Pravin U. Dugel MD Managing Partner, Retinal Consultants of Arizona Phoenix AZ Clinical Professor USC Eye Institute Keck School of Medicine Los Angeles CA Medical Research: What is the background for this study? What are the main findings? Dr. Dugel: Endophthalmitis is one of the most feared complications in ophthalmology. It is potentially...
MedicalResearch.com Interview with:
Prof. David Mackey
Centre for Ophthalmology and Vision Science/Lions Eye Institute Perth
Managing Director/Chair of University of Western Australia,
Perth, Australia
Centre for Eye Research Australia, Melbourne University
MedicalResearch: What is the background for this study? What are the main findings?
Prof. Mackey: Too much or too little sun? Excessive sun exposure is associated with the eye disease pterygium, while lack of outdoor activity in childhood increases the risk of myopia (short sightedness).
Measuring the amount of early sun damage to a person’s eyes would be of great use to researchers and potential use in clinical practice.
Over the last few years we have developed a biomarker for sun exposure to the eye by photographing Conjunctival UV Auto-Fluorescence (CUVAF).
The study published in JAMA Ophthalmology looked at the genetic and environmental factors that contribute to CUVAF levels in three Australian studies from Tasmania, Perth and Brisbane.
People who live in sunnier environments closer to the equator have more evidence of sun damage using CUVAF. However, genetic factors also play a role.
MedicalResearch.com Interview with
Ronald C Gentile, MD, FACS, FASRS
Professor of Ophthalmology
Chief, Ocular Trauma Service (Posterior Segment)
Surgeon Director
The New York Eye and Ear Infirmary of Mount Sinai
New York, NY 10003
President: operationrestorevision.org
Medical Research: What are the main findings of the study?
Dr. Gentile: We had three main findings in our study on the microbiological spectrum and antibiotic sensitivity in endophthalmitis over the past twenty- five years at the New York Eye and Ear Infirmary of Mount Sinai.
First Finding: The first main finding of the study was that there has not been any major change in the types of organisms causing endophthalmitis over the past 25 years. The most common cause of endophthalmitis in the study was bacteria, 95%, with most, 85%, being Gram-positive bacteria. The most prevalent organisms isolated were coagulase-negative staphylococcus, making up about 40% of the cases. This was followed by Streptococcus viridans species in about 12% and Staphylococcus aureus in about 11%. Gram-negative organisms accounted for about 10% and fungi for about 5%.
Second Finding: The second main finding of the study was that the current empiric intravitreal antibiotics used for treating endophthalmitis, vancomycin and ceftazidime, continue to be an excellent choice. The overwhelming majority of microorganisms causing endophthalmitis are susceptible to this combination. Over 99% of the Gram-positive isolates were susceptible to the vancomycin and about 92 percent of the Gram-negative isolates were susceptible to ceftazidime.
Third Finding: The third main finding of the study was that there was increasing microbial resistance to eight antibiotics including cefazolin, cefotetan, cephalothin, clindamycin, erythromycin, methicillin/oxacillin, ampicillin, ceftriaxone and decreasing microbial resistance to three antibiotics including gentamicin, tobramycin, and imipenem. For example, Staph Aureus isolates resistant to methicillin increased from 18% in the late 1980s to just over 50% this past decade while gentamicin-resistance endophthalmitis isolates decreased during the same time period from 42% to 6%.
MedicalResearch.com Interview with:
Dr. Flora Lum, MD
Executive Director, The H. Dunbar Hoskins Jr., M.D. Center for Quality Eye Care,
American Academy of Ophthalmology
San Francisco, CA 94109-1336
MedicalResearch.com: What are the main findings of the study?
Dr. Lum: This study anticipates the increased use of claims data for research.
The study recommends a checklist for authors to use in reporting claims data analyses, and discusses the advantages and limitations of using claims data.
MedicalResearch.com: Were any of the findings unexpected?
Dr. Lum: There is variability in the methods and descriptions of claims data analyses, and as these increase in number and importance, its encouraged that researchers use rigorous methods.