Aging, Author Interviews, Dermatology / 19.02.2024

MedicalResearch.com Interview with: Frank Wang MD William B. Taylor Endowed Professor of Clinical Dermatology Associate Professor, Dermatology Associate Chair for Education Assistant Program Director, Dermatology Residency Program University of Michigan Ann Arbor, Michigan MedicalResearch.com: What is the background for this study? How is the cross-linked hyaluronic acid obtained? Where was it injected? Response: As the skin undergoes photoaging due to chronic exposure to ultraviolet light, it loses dermal collagen, which in turn leads to wrinkling, lines, and loss of support. The loss of collagen is, in large part, due to reduced function of the skin’s collagen-producing cells, dermal fibroblasts. We wanted to investigate whether it was possible to reverse the decreased function of fibroblasts in photodamaged skin, by introducing a space-filling material into the dermis, injected CL-HA dermal filler. The CL-HA filler we used was donated to us for research purposes. We performed injections of CL-HA into the mid-dermis (as is normally done when injected into the face) of severely photoaged forearm skin of human participants over the age of 60. We then examined skin samples at various time points, including 1, 2, 3 and 4 weeks and 3, 6, 9, and 12 months post-injection. (more…)
Author Interviews, Surgical Research / 10.09.2014

Achih H. Chen, MD, FACS, FAACS Georgia Center for Facial Plastic Surgery, Evans, Ga and the Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery Georgia Regents University, August, GaMedicalResearch.com Interview with: Achih H. Chen, MD, FACS, FAACS Georgia Center for Facial Plastic Surgery, Evans, Ga and the Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery Georgia Regents University, August, Ga Medical Research: What is the significance of the study? Dr. Chen : This is the first time that facial rejuvenation surgery using surgical approaches in three planes combined with ablative resurfacing has been reported in the medical literature. This approach was not previously thought possible in a single surgical setting because of the concern about disrupting the facial blood supply that may result in loss of the skin. The study demonstrates the safety of this “Total Face” approach. This approach allows simultaneous tightening of the jawline and neck, recreating the lost youthful volume of the midface region, and restoring of the smooth skin texture so characteristic of a young face. This allows for a more complete or “Total Face Rejuvenation” for patients while allowing them the flexibility for a single recovery period or downtime. (more…)