Introduction
When most people think of Botox, they picture its well-known use in reducing the appearance of wrinkles and fine lines. It has long been associated with achieving a more youthful appearance, but there’s so much more to Botox than just cosmetic enhancement. Originally developed for medical purposes, Botox has proven to be a versatile treatment for various conditions beyond aesthetic improvements.
At Mega Dental Willow Grove, patients are becoming increasingly aware of the wide range of therapeutic benefits Botox can offer. From easing chronic pain to helping manage severe medical conditions, Botox has been gaining recognition as a powerful tool in modern medicine. In this blog, we will explore the surprising and beneficial ways Botox can improve your quality of life beyond simply rejuvenating your skin.
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Dermal fillers are becoming more popular for people who want to look younger without surgery. These injections from professionals like Transformation Aesthetics can smooth out wrinkles and add volume to your face. There are several types of dermal fillers, each with its own unique properties and uses.Many patients curious about fillers but unsure where to start. It's important to know that different fillers work best for different areas of the face. Some are great for plumping lips, while others excel at filling in deep lines around the mouth or eyes.When thinking about getting fillers, it's crucial to talk with a skilled doctor. They can help you pick the right type for your goals and explain what to expect. Fillers can give quick results, but they don't last forever. Most need to be redone every few months to a year.(more…)
Botox treatment was created to make undesirable physical lines less visible. It is an efficient way to bring the natural facial appeal back to its normal condition. By getting quick and painless Botox injections, you can maintain the appearance you want most. There are a lot of myths surrounding the treatment, but the popularity of Botox is a very real thing.
The Stars Know
When you hear about Botox, it is usually attached to a celebrity story. This type of treatment is very popular in Hollywood circles, and for good reason. It is an effective way to keep a specific look without major cosmetic surgery.
When time is of the essence, Botox has no equal. You can set up an appointment, get the injections, and see results as early as three days. That is a single weekend required to get good looking results without breaking the bank. Hollywood is a business that relies on looks, so the popularity of Botox is no surprise. Its effectiveness on the most beautiful people in the world is the main reason why it’s still trending.
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MedicalResearch.com Interview with:
Dr. Melanie D. Palm, MD, MBA
Board-certified dermatologist and cosmetic surgeon
San Diego, CA
Clinical investigator in the Restylane Kysse phase 3 Galaderma trialDr. Palm discusses the recent announcement that the FDA has approved Restylane® Kysse for lip augmentation and the correction of upper perioral rhytids (wrinkles) in adults over the age of 21.MedicalResearch.com:What is the background for this announcement?
Restylane® Kysse has been approved and used in Europe and Canada for several years. It is now the first FDA-approved hyaluronic acid (HA) lip filler in the U.S. formulated with XpresHAn Technology™ (pronounced ex-'spre-shan’) for smooth, natural-looking results.
It is FDA-approved for use not only in the lip but for improvement of upper lip lines.
Restylane Kysse is the third product (following Restylane Defyne and Restylane Refyne) in the Restylane family of fillers to use XpresHAn Technology™ which allows for a gel that integrates into the skin for natural expression in motion
MedicalResearch.com Interview with:
Keshav K. Singh, Ph.D.
Joy and Bill Harbert Endowed Chair in Cancer Genetics
Professor of Genetics, Pathology and Environmental Health
Founding Editor-in-Chief, Mitochondrion Journal
Director, Cancer Genetics Program
The University of Alabama at Birmingham
Birmingham, AL 35294
MedicalResearch.com: What is the background for this study? What are the main findings?Response: Decline in mitochondrial DNA content and mitochondrial function has been observed in aging humans. We created mouse to mimic those condition to show that decline in mitochondrial function leads to development of wrinkles and loss of hair.
The main finding is that by restoring mitochondrial function we can reverse skin wrinkles to normal healthy skin and also regain hair growth.(more…)
MedicalResearch.com Interview with:
Boris Paskhover, MD
Associate Professor,Department of Otolaryngology-Head and Neck Surgery
Rutgers New Jersey Medical School
MedicalResearch.com: What is the background for this study? What are the main findings?Response:Facial fillers include a wide range of cosmetic products used by physicians for augmenting the face. Some fillers are permanent, while others are temporary. Lip filler material is included in this category. Any physician is allowed to perform these procedures but patient’s need to be aware that these are not benign procedures and have some serious complications. It’s important to always go to an experienced facial plastic surgeon, general plastic surgeon or possibly dermatologist for your aesthetic fillers. Our study detailed a decade-long review of FDA reported complications with aesthetic fillers. (more…)
MedicalResearch.com Interview with:
David Granville, BSc, PhD, FAHA
Professor, University of British Columbia
Scholar of the Royal Society of Canada
Director, GEM Facility, Centre for Heart Lung Innovation, St. Paul's Hospital Founder and CSO, viDA Therapeutics, Inc.
Vancouver, BC, Canada
Medical Research: What is the background for this study? What are the main findings?Dr. Granville: My background is in cardiovascular research. In particular, how age affects blood vessels and how age affects mechanisms of blood vessel and heart injury and repair. We became interested in skin aging during a study in which we were studying the role of a protein degrading enzyme known as Granzyme B in atherosclerosis (hardening of the arteries) and aging. In these studies, we were using a genetic mouse model that is prone to accelerated aging, and knocked out Granzyme B. Although we were initially focused on the blood vessels, we also found that Granzyme B-deficient mice exhibited younger-looking skin. As we started to look into this, we became aware that UV light can induce the skin cells to produce Granzyme B. As sunlight is believed to be responsible for 80-90% of preventable skin aging, we generated a solar-simulated light box (with the similar ratios of UVA/UVB to sunlight) to assess whether Granzyme B played a role in UV-induced skin aging (aka photoaging). We exposed the mice to repetitive, low dose UV three times per week for 20 weeks. After 20 weeks we observed that Granzyme B deficient mice exhibited fewer wrinkles. We then wanted to look histologically and biochemically into how Granzyme B was affecting skin morphology. Granzyme B deficient mice exhibited greater collagen density compared to mice that possessed Granzyme B. As we looked into the mechanism in more detail, we determined that Granzyme B was cleaving a protein known as decorin. Decorin is responsible for collagen fibrillogenesis and assembling collagen into tight bundles. Loss of decorin is associated with a loss of collagen tensile strength. Interestingly, decorin also protects collagen from destruction by a protein-degrading enzyme known as MMP1. We showed in the study that by breaking down decorin, Granzyme B renders collagen susceptible to MMP1-mediated degradation. In addition, we showed that Granzyme B-fragmentation of another protein, fibronectin, led to the upregulation of MMP1 in skin fibroblasts. In summary, the paper showed that UV induced Granzyme B expression in the skin and showed that this enzyme contributes to the breakdown of extracellular matrix proteins and formation of wrinkles.
A link to the Aging Cell publication: http://onlinelibrary.wiley.com/doi/10.1111/acel.12298/pdf(more…)
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