Intestinal Microbiome May Contribute To Burn Pathology Interview with:
Mashkoor A.  Choudhry, PhD

Professor of Surgery, Microbiology & Immunology
Burn & Shock Trauma Research Institute
Stritch School of Medicine
Loyola University Chicago Health Sciences Division
Maywood, IL 60153

Medical Research: What is the background for this study? What are the main findings?

Dr. Choudhry: Intestine is the major reservoir of bacteria in the body. We observed that gut bacterial composition is altered after burn injury. We found that burn causes a significant increase in Enterobacteriaceae, a group of bacteria that has the potential to be harmful for the host. Dysbiosis of the healthy intestinal microbiome is associated with a number of inflammatory conditions.

Medical Research: What should clinicians and patients take away from your report?

Dr. Choudhry: Although based on limited number of patients, our findings suggest that changes in the intestinal microbiome can potentially contribute to pathology associated with burns, however more studies are required to establish this link.

Medical Research: What recommendations do you have for future research as a result of this study?

Dr. Choudhry: As I indicated above that our current study is based on limited number of patients, so more studies are needed to confirm these findings with large burn patient population. Additionally more research is also needed to investigate the mechanism by which burn injury results in the dysbiosis of normal gut microbiota.


Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation.

Zachary M. Earley, Suhail Akhtar, Stefan J. Green, Ankur Naqib, Omair Khan, Abigail R. Cannon, Adam M. Hammer, Niya L. Morris, Xiaoling Li, Joshua M. Eberhardt, Richard L Gamelli, Richard H. Kennedy, Mashkoor A. Choudhry

Published: July 8, 2015
DOI: 10.1371/journal.pone.0129996

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Mashkoor A. Choudhry, PhD (2015). Intestinal Microbiome May Contribute To Burn Pathology 

Last Updated on September 17, 2015 by Marie Benz MD FAAD