04 May Learning from Mice How Tissues Communicate With Each Other
MedicalResearch.com Interview with:
Marcus M. Seldin PhD (Post-doc researcher) and Professor Aldons J. Lusis, PhD
Department of Medicine, Department of Human Genetics
Department of Microbiology, Immunology and Molecular Genetics
University of California, Los Angeles, CA,
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: There are thousands of proteins which circulate in the blood and relay signals between tissues, however many of their functions remain difficult to dissect. We used a mouse population, termed the Hybrid Mouse Diversity Panel (HMDP) to ask if we can identify new factors which communicate between tissues. Taking this approach, we uncover several proteins which relay signals between tissues. These include Lipocalin-5, an adipose-expressed protein which can promote skeletal muscle respiration and liver-derived Notum which enhances thermogenesis in fat tissue. The approach we developed can also be broadly applied to many mouse and human datasets. As proof of this, we show that cross-tissue predictions are remarkably conserved between mice and humans
MedicalResearch.com: What should readers take away from your report?
Response: This is a new method to identify new circuits of tissue-tissue communication, which we validate in mice.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: This generalized approach can be applied to many other datasets to infer new modes of tissue-tissue communication. In addition, follow-up studies involved the proteins we uncovered will help guide their conserved functional roles and potential translation
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism
Seldin, Marcus M. et al.
Cell Metabolism , Volume 27 , Issue 5 , 1138 – 1155.e6
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