MedicalResearch.com Interview with:
Begoña Ruiz Núñez PhD (c)
Laboratory Medicine UMC Groningen
Co-directora de Healthy Institute
President of the Asociación Española de Psico-Neuro-Inmunologí
MedicalResearch.com: What is the background for this study?
Response: The diagnosis of Chronic Fatigue Syndrome (CFS) is based on the Fukuda criteria, i.e. symptoms, disability, and exclusion of explanatory illnesses, and not by means of physical signs or abnormalities in laboratory test results. CFS has been described as a ´allostatic overload condition´, where the physiological mechanisms employed to deal with stress contribute to the perpetuation of the disorder. Chronic Fatigue Syndrome patients are 1.9 times more likely to have a high allostatic load index than healthy controls. Thyroid allostasis-adaptive responses, presenting as non-thyroidal-illness syndrome, have been found in many conditions, ranging from critical illness, uremia and starvation to tumors. Taken together, it is possible that, despite TSH and T4 levels within reference ranges, Chronic Fatigue Syndrome symptoms may be attributable in part to allostatic responses, i.e. lower thyroid hormone activity, secondary to chronic (low-grade) inflammation caused by e.g. a compromised gut microbiome and gut wall integrity.