26 Sep Long Term Antibiotics May Harm Immune Cells of Gut and Mucous Membranes
MedicalResearch.com Interview with:
Pushpa Pandiyan, PhD
Assistant Professor, Biological Sciences
School of Dental Medicine
Case Western Reserve University
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The objective was to find the role of the resident bacteria in the mouth in controlling oral immunity.
We examined this in a oral fungal infection model. How resident microbiome in the mouth maintains a healthy oral immune system was unknown before.
We found that antibiotics led to destruction of microbiome and some of the good fatty acids the bacteria produced. This created an immune imbalance in the local tissue, thus making the host more susceptible to the fungal infection.
MedicalResearch.com: What should readers take away from your report?
Response: That long term antibiotics could destroy some of the critical immune cells in the mouth, gut and other mucosa.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: Antibiotics should be avoided when possible.
Front Microbiol. 2018 Aug 24;9:1995. doi: 10.3389/fmicb.2018.01995. eCollection 2018.
Role of Short Chain Fatty Acids in Controlling Tregs and Immunopathology During Mucosal Infection.
Bhaskaran N1, Quigley C1, Paw C1, Butala S1, Schneider E1, Pandiyan P1.
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